• Journal of Infectious diseases

Antibody Combinations Targeting the Essential Antigens CyRPA, RH5, and MSP-119 Potently Neutralize P

Updated: May 3, 2021

Hina Singh, Syed Yusuf Mian, Alok K Pandey, Sri Krishna, Gaurav Anand, K Sony Reddy, Neha Chaturvedi, Vanndita Bahl, Nidhi Hans, Man Mohan Shukla, Quique Bassat, Alfredo Mayor, Kazutoyo Miura, Praveen K Bharti, Carole Long, Neeru Singh, Virander Singh Chauhan, Deepak Gaur


Abstract

Background


Targeting multiple key antigens that mediate distinct Plasmodium falciparum erythrocyte invasion pathways is an attractive approach for the development of blood-stage malaria vaccines. However, the challenge is to identify antigen cocktails that elicit potent strain-transcending parasite-neutralizing antibodies efficacious at low immunoglobulin G concentrations feasible to achieve through vaccination. Previous reports have screened inhibitory antibodies primarily against well adapted laboratory parasite clones. However, validation of the parasite-neutralizing efficacy against clinical isolates with minimal in vitro cultivation is equally significant to better ascertain their prospective in vivo potency.


Link to the journal: https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiaa608/5912652


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